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Considering the above summarized data and the various hypotheses put forward that attempt to explain the comorbidity of psychiatric disorders with substance use, in the case of alcohol and depression it appears that there is some familiar aggregation that would support the first hypothesis of common neurobiological substrates with different symptomatic expressions, although there is much data that are not supportive of this genetic linkage. Advances in behavioral biology. Presynaptic and postsynaptic modifications of the serotonin system by long-term administration of antidepressant treatments: an in vivo electrophysiologic study in the rat.

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